We present the first series of patients treated by transoral laser surgery (TLS) using the new AcuPulse 40WG CO2 laser with the FiberLase flexible waveguide (CO2 LWG) (Lumenis, Santa Clara, CA) with the objective to test its reliability and efficacy. Patients older than 18 years, with
oral, pharyngo-laryngeal or tracheal benign or premalignant lesions were enrolled after signing an informed consent. This
prospective study was conducted between October 2010 and May 2011 in two tertiary care university hospitals. Thirty-nine patients
were enrolled in the study. The mean age was 47.9 years (range 18â

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