Abstract  It has been demonstrated that experiences taking place early in life have a profound influence on brain development, interacting
with the genetic background and determining differences in the vulnerability to the onset of bipolar disorder when the individual
is exposed to a second adverse event later in life. Here, we investigated the effects of exposure to an early adverse life
event (maternal deprivation) and to a later adverse life event [d-amphetamine (AMPH)] on cognition in an animal model of mania. We have previously demonstrated that that repeated AMPH exposure
produces severe and persistent cognitive impairment, which was more pronounced when the animals were maternal deprived, suggesting
that the early adverse life event could be potentiating the effects o...

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