Abstract This paper reviews non-invasive behavioural approaches – broadly construed as cognitive, affective, behavioural and psychophysiological interventions – and examines whether they can impact central, peripheral or autonomic nervous system components responsive to pain in general and headache in particular. It focuses on two developing bodies of literature – neurophysiology of migraine and fMRI studies of pain networks. The available literature suggests behavioural interventions can affect neuromodulation, although further research is clearly warranted. Content TypeJournal Article JournalNeurological SciencesOnline ISSN 1590-3478Print ISSN 1590-1874 Journal VolumeVolume 28 Journal IssueVolume 28, Supplement 2 / May, 2007 (Source: Neurological Sciences)

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