Abstract  Deep brain stimulation (DBS) extends the treatment of some severe neurological diseases beyond pharmacological and conservative
therapy. Our experience extends the field of DBS beyond the treatment of Parkinson disease and dystonia, including several
other diseases such as cluster headache and disruptive behavior. Since 1993, at the Istituto Nazionale Neurologico “Carlo
Besta” in Milan, 580 deep brain electrodes were implanted in 332 patients. The DBS targets include Stn, GPi, Voa, Vop, Vim,
CM–pf, pHyp, cZi, Nacc, IC, PPN, and Brodmann areas 24 and 25. Three hundred patients are still available for follow-up and
therapeutic considerations. DBS gave a new therapeutic chance to these patients affected by severe neurological diseases and
in some cases controll...

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