Authors: Rojas DB, Gemelli T, de Andrade RB, Campos AG, Dutra-Filho CS, Wannmacher CM
Abstract
Histidinemia is an inherited metabolic disorder biochemically characterized by high concentrations of histidine in biological fluids. Usually affected patients are asymptomatic although some individuals have mental retardation and speech disorders. Considering the high prevalence of histidinemia and the scarce information on the effects of maternal histidinemia on their progeny, we investigated various parameters of oxidative stress in brain cortex and hippocampus of the offspring from female rats that received histidine (0.5Â*mg/g of body weight) in the course of pregnancy and lactation. At 21Â*days of age we found a significant increase of thiobarbituric acid reactive substances (TBARS)...

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